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To study the permeability of nanoparticles in vitro BBB models, which conform to the 3R principles with the minimalization the number of animal experiments, are widely used either in static [34] or in dynamic conditions by employing lab-on-a-chip systems [35]

Pietrzkowski Z, Mulholland G, Gomella L, et al

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Thus, ventricular mechanical efficiency rose from 9+/-2 to 21+/-5 percent (P=0.006)